The REDUCE-IT trial (2018) demonstrated that 4 g/day of icosapentaenoic acid (EPA) reduced major cardiovascular events by 25% in adults with elevated triglycerides already on statin therapy. DHA is particularly concentrated in neuronal membranes — constituting 25–35% of brain grey matter fatty acids — and in photoreceptor outer segments of the retina.
Practical Supplementation
- 2–4 g EPA+DHA daily for meaningful cardiovascular and anti-inflammatory effects
- Triglyceride-form omega-3 (from fish oil) is better absorbed than ethyl-ester form
- Algal omega-3 is the vegan/vegetarian equivalent — derived from marine algae
- Store in the fridge or freezer after opening — omega-3 oils oxidise rapidly at room temperature
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