Phosphatidylserine blunts exercise-induced cortisol spikes and may protect your brain from chronic stress

Phosphatidylserine (PS) is a phospholipid found in high concentrations in neuronal cell membranes. It is one of the few dietary supplements to receive a qualified FDA health claim for cognitive function. A 1992 study found that 800 mg PS per day for 10 days reduced exercise-induced cortisol by 20% in healthy young men. A 1994 study demonstrated dose-dependent cortisol and ACTH blunting at 400 mg and 800 mg/day.

Cognitive Applications

• 100–400 mg per day is the dose range used in cognitive function studies
• Most notable evidence is in older adults — improvements in memory, learning, and attention
• PS works synergistically with DHA omega-3 — they are co-components of neuronal membranes
• No significant adverse effects at studied doses; mild GI upset at higher doses in some individuals